AMP case report: August 2017 test yourself answers

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In the August 2017 issue was a report, “NGS panel aids in diagnosis of rare collision tumor,” written by members of the Association for Molecular Pathology. Here are answers (in bold) to the three “test yourself ” questions that followed that case report.

1. Which of the following are included in the differential diagnosis of spindle cell lesions of the gastrointestinal tract?

a) Sarcomatoid carcinoma

b) Gastrointestinal stromal tumor

c) Metastatic leiomyosarcoma

d) Sarcomatoid mesothelioma

e) All of the above

2. Which of the following is not a gene that encodes for a mismatch repair protein?

a) MLH1

b) MSH2

c) MSH6

d) BRCA2

e) PMS2

3. Activating mutation in the BRAF gene in colorectal carcinoma correlates most closely with which of the following?

a) Hypermethylation of the MLH1 gene promoter

b) Somatic loss-of-function mutation in the MLH1 gene

c) Germline loss-of-function mutation in the MLH1 gene

d) Loss of heterozygosity at the MLH1 gene locus