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Sciex launches high-performance MS/MS system

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Jan. 31, 2018Sciex Diagnostics announced the launch of the Citrine Triple Quad MS/MS and Citrine Qtrap MS/MS Systems for clinical diagnostics.

The Citrine MS/MS system enables the measurement of trace levels of biomarkers and metabolites at sub-pg/mL concentrations, comprehensive multianalyte panels, and the measurement of large and small molecules. Qtrap technology enables workflows that provide quantitative and qualitative analysis in a single injection and allows the use of highly selective MRM3.

The system is powered by Analyst MD software for instrument control and data processing. The second-generation IonDrive Turbo V ionization source provides robust, reliable performance when analyzing complex biological samples, maximizes uptime, and offers simplified sample preparation.

The system includes electrospray ionization and atmospheric chemical ionization options, an extended mass range up to m/z 2,000, and a wide linear dynamic range. These features, the company said, make this a versatile tool for the measurement of a large variety of polar and non-polar biomarkers and metabolites in biological fluids over a large range of concentrations.

“Reliable quantitative measurement of trace level compounds such as steroidal hormones is extremely difficult. While traditional immunological methods offer high sensitivity, they rely on the selectivity of the antibody used and are prone to misidentification,” Rao Maddipatti, PhD, associate professor, Department of Pathology, and director, Lipidomics Core Facility, Wayne State University, said in a release from Sciex. “Mass spectrometric quantification alleviates such concerns of selectivity. With the ultrasensitive Citrine MS/MS system, not only can these trace level steroids be measured with confidence, but the analyses can also multiplex over a hundred compounds in a single experiment, allowing clinicians and patients to benefit from a bird’s eye view of the metabolome.”

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