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Chrono-log Corp., Whole Blood Optical Lumi-Aggregation System 700-2, 700-4 (Coagulation 2019)

Chrono-log Corp., Whole Blood Optical Lumi-Aggregation System 700-2, 700-4 (Coagulation 2019)

Coagulation analyzers, January 2019

Contact Information

Chrono-log Corp.
Kathy Jacobs
Havertown, PA
610-853-1130 or 800-247-6665

Instrument name/First year sold Whole Blood Optical Lumi-Aggregation System 700-2, 700-4/2006
Number of units installed in U.S./Outside U.S. 160/205
Number of contracts signed between 1/1/18 and 11/15/18
Country where analyzer designed/Manufactured U.S./U.S.
Operational type batch, random access
Reagent type open reagent system, assay kits, reference plasmas, controls (lyophilized, reconstituted manually)
Operates on whole blood or spun plasma whole blood, spun plasma
Sample handling system manual
Model type benchtop
Dimensions (H × W × D)/Weight/Instrument footprint 8.5 × 14 × 18 in./40 lbs./M700-2: 1.75 sq. ft.; M700-4: 3.5 sq. ft.
FDA-cleared clotting-based tests
FDA-cleared chromogenic tests
FDA-cleared immunologic tests
Other FDA-cleared tests platelet-dense granule secretion, whole blood impedance aggregation, LTA aggregation, ristocetin cofactor assay
User-defined tests in clinical use platelet-dense granule secretion, whole blood impedance aggregation, LTA aggregation with all standard reagents, ristocetin cofactor assay
Tests submitted for 510(k) clearance
Tests in development but not yet submitted
Methodologies supported turbidimetric, platelet-dense granule secretion, whole blood impedance aggreg., LTA aggreg., ristocetin cofactor assay
Operator must load sep. reagent pack per specimen/Test run no/—
Number of different measured assays onboard simultaneously 2–4
Number of different assays programmed and calib. at one time 4–8
Number of user-definable (open) channels 2–4
Of those defined, number active simultaneously 2–4
Factor assays require manual manipulation or dilutions yes
Number of reagent containers onboard at once/Tests per container/Reagents refrigerated onboard no/—/no
Multiple reagent configurations supported yes
Reagents, consumables loaded without interrupting testing yes
Same capabilities when third-party reagent used no
Maximum time same lot number of reagents can be used 12–30 months
Walkaway capacity: Number of specimens/Number of tests 2–4/4–8
Minimum sample volume aspirated precisely at one time
Standard specimen volume required to run PT or PTT/ Factor VIII activity 225 µL PRP-lumi aggregation 450 µL; 450 µL whole blood-lumi aggregation 450 µL/25 µL ristocetin cofactor 50 µL
Disposables used/Price of each cuvettes: 144 @ $34; stir bars: 144 @ $30; impedance probes: 25 @ $130; pipette tips: 1,000 @ $73, $55, and $60
Supports direct-from-track sampling no
Primary tube sampling supported/Pierces caps on primary tubes no/no
Sample/Reagent barcode reading capability no/no
Onboard test automatic inventory no
Measures No. of tests remaining/Short sample detection no/no
Clot detection as preanalytical variable in plasma sample no
Auto. detects adequate reagents for aspiration and analysis no
Hemolysis/Turbidity detection-quantitation no/no
Dilution of patient samples onboard no
Automatic rerun capability/Auto reflex testing capability yes/no
Lag time during which hypercoagulable sample not detected
Read time extended for prolonged clotting times yes
User can set different-than-standard:
• Reagent volumes/Sample volumes yes/yes
• No. and sources of reagent yes
• Incubation times/Reading times yes/yes
Autocalib. or autocalib. alert/Multipoint calib. supported yes/—
Auto shutdown/Auto startup programmable no/no
Stat time to complete all analytes/Throughput per hour for:
• PT alone
• Fibrinogen
• Factor VIII activity assay
Time delay from ordering stat to aspiration of sample
Automatic transfer of QC results to LIS no
Data-management capability onboard
Interface supplied by instrument vendor yes
Interfaces in active user sites for:
Bidirectional interface capability no
Results transferred to LIS as soon as test time complete no
LOINC codes transmitted with all results no
How labs get LOINC codes for reagent kits
Electronic interface available (or will be) to automated (or robotic) specimen handling system no
Modem servicing no
Time required for maintenance by lab personnel 30 minutes when optical calibration required
Onboard maintenance records yes
Training provided with purchase 1.5 days on site
Approximate number of training hours needed per tech 8
List price M700-2: $19,500; M700-4: $32,000
Annual service contract cost (24/7)/Warranty with purchase M700-2: $1,804; M700-4: $3,008 for 3 years/1 year
Distinguishing features (supplied by company) tests platelet aggregation; measures ATP release in 4 samples simultaneously using whole blood, PRP, washed, or gel-filtered platelets; continuously monitors temp. and stirring speed; optical calibration by lab personnel; dedicated software packages calculate amplitude, slope, lag time, and more
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