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Horiba Medical, Pentra C400 (Chemistry-Immunoassay POC Low Volume, 2018)

Horiba Medical, Pentra C400 (Chemistry-Immunoassay POC Low Volume, 2018)

Chemistry and immunoassay analyzers for point-of-care and low-volume laboratories, June 2018

Contact Information

Horiba Medical
Ed Salanga
Irvine, CA

Name of instrument Pentra C400
Type of instrument chemistry
Operational type/Model type batch, random access, continuous random access, discrete/benchtop
List price/First year sold in U.S. $100,000/2006
Targeted hospital bed size/Targeted daily test volume ≤ 250/1,200
Company manufactures instrument yes (also sold by Henry Schein, McKesson, Thermo Fisher, Medline, LSI)
Other models in this family of analyzers
No. of units in clinical use in U.S./Outside U.S. (countries) 600/ 1,800
Dimensions (H × W × D)/Instrument footprint (square feet) 25 × 40 × 28 in./7.7 sq. ft.
Weight empty/Weight fully loaded 264 lbs./266 lbs.
Tests available on analyzer in U.S. total protein, chloride, glucose, magnesium, triglycerides, amylase, cholesterol, BUN, iron, ferritin, TIBC, transferrin, uric acid, total bilirubin, creatinine, lactic acid, potassium, more
Tests not available in U.S. but available in other countries apolipoprotein A1, apolipoprotein B, beta 2 microglobulin, fructosamine, CK-MB, anti-strep O, haptoglobin, more
Tests in development for analyzer
No. of different measured assays onboard simultaneously 55 (55 can be run and calibrated at one time)
No. of user-definable (open chemistry) channels 40 (40 can be active simultaneously)
Test throughput per hour/Assay run time 420 (4 tests in throughput)/1–10 min. (avg. 5 min.)
No. of direct ion-selective electrode channels 3
Detection methods photometry, potentiometry, enzyme immunoassay
Stat time until completion/specimen throughput for:
• Ion-selective electrode < 5 min./37 specimens per hr.
• Basic metabolic panel < 7.5 min./35 specimens per hr.
• Complete metabolic panel < 11 min./23 specimens per hr.
Typical time delay from ordering stat test until aspiration of sample < 1 min.
Fully automated microplate immunoassay system
Methodologies supported
Separation methodologies
Stat time until completion of a ß-hCG test
Typical time delay from test order to aspiration of sample
Stat time until completion of a cTn test
• Typical time delay from test order to aspiration of sample
Approx. No. of tests per reagent set or pack/Reagent type 100–400/self-contained multiuse, open reagent system
Reagents refrigerated onboard/Reagents ready to use yes (2°–8°C)/yes
Reagent lot tracking/Reagent inventory yes/yes
Reagent form/Reagents barcoded liquid chemistry (open reagent system)/yes
Separate reagent pack for each specimen/for each test run no/yes
Walkaway capability/Walkaway duration yes/180 min. or 60 specimens or > 800 tests/assays
Design of sample handling system rack
Uses washable cuvettes/Uses disposable cuvettes no/yes (can store up to 432 cuvettes)
Min.–max. sample volume that can be aspirated at one time 2–60 µL
Min. reaction volume/Min. specimen volume/Min. dead volume 180 µL/300 µL/100 µL
Dedicated pediatric sample cup yes (dead volume: 100 µL)
Primary tube sampling/Pierces caps on primary tubes yes (tubes [in mm]: 13 × 75, 13 × 100, 16 × 100)/no
Protects against probe collision yes
Detects clots/liquid level/short sample yes/yes/yes
Detection for hemolysis/icterus/lipemia/clots no/no/no/yes
Dilutes patient samples onboard/Susceptibility to carryover yes (can be programmed to perform dilutions prior to analysis)/0
Automatic rerun capability yes
Sample volume can be diluted to rerun out-of-linear-range high results/concentrated to rerun out-of-linear-range low results yes/no
Analyzer requires dedicated water supply no (average of .5 L/hr. consumption during operation)
Autocalibration/Multipoint calibration supported yes (calibrants can be stored onboard)/yes (recommended avg. frequency: 14 days)
Typical calibration frequency for ISE/therapeutic drugs/ drugs of abuse/general chemistries/immunoassays 2 hrs. automatic/—/—/14 days avg./—
Automatic programmable start/Automatic programmable shutdown yes (5 min. avg. start-up time)/—
Onboard real-time QC/Onboard software capability to review QC yes/yes
Supports multiple QC lot numbers per analyte no
Waste management direct to drain or container if no drain available
Sample barcode-reading capability/Autodiscrimination yes (Interleaved 2 of 5, UPC, Codabar, Code 39, Code 128)/yes
Lab can control analyzer from remote computer no
Instrument can diagnose its own malfunctions yes (operator intervention required to order parts)
System malfunctions can be diagnosed via remote monitoring yes
UPS backup power supply/Data-management capability no/onboard
LIS or EHR systems interfaced CGM LabDaq, Orchard, Cerner, Sunquest, Meditech, Schuyler House
LIS interface provided/Bidirectional interface capability no/yes (broadcast download and host query)
Modem servicing provided/Service engineer on-site response time no/< 24 hrs.
Mean time between failures 2 per year avg. (displays error codes for troubleshooting)
Average scheduled maintenance time by lab personnel daily: < 5 min.; weekly: < 15 min.; monthly: < 30 min.
Maintenance records kept onboard for user/vendor yes (includes audit trail of who replaced parts)/no
Maintenance training demonstration module onboard no
Training included with purchase/Avg. time for basic user training yes (3 training slots)/2 days (location is user preference)
Advanced operator training/Where advanced training is held yes (extra charge)/vendor site
Warranty provided/Cost of annual service contract (24 h/7 d) yes (1 year)/—
Distinguishing features (supplied by company) • can run up to 55 assays onboard with 420 quality results/hr. • no requirement for an external water system; remote diagnostics available for real-time troubleshooting • flexible, open-channel system with capability of having 40 third-party reagents onboard
Note: a dash in lieu of an answer means company did not answer question or question is not applicable
All information is supplied by the companies listed. The tabulation does not represent an endorsement by the CAP.