April 2024—The rise in fungal infections in recent years troubles Sean Zhang, MD, PhD, for reasons near and far. It’s readily apparent in the patient populations at Johns Hopkins Hospital, where he is director of the mycology laboratory. Especially concerning is the increase in Candida auris following the height of the COVID-19 pandemic, both in terms of colonization and infection cases, says Dr. Zhang, who is also associate professor of pathology, Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine. “Since 2022, we suddenly saw an uptick in Candida auris cases across the Johns Hopkins Health System.” But the situation isn’t unique to Johns Hopkins. Pointing to CDC figures, he notes that the tide is rising more broadly as well. The agency reports that in 2020, there were 757 clinical cases and 1,310 screening cases of C. auris in the United States. In 2022, there were 2,377 clinical cases and 5,754 screening cases.
Read More »APRIL 2024
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Confronting diagnostic gaps in fungal infection
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Hybrid practice model beckons as solution
April 2024—With the technology now available, could and should remote diagnostic pathology, or at least a hybrid model, become more the norm in the future? Timothy Craig Allen, MD, JD, and Casey P. Schukow, DO, of Corewell Health in Michigan, in an editorial published recently, say the time for one or the other or both has come.
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Need for speed in solid tumor molecular testing
April 2024—As the call for fast turnaround of genetic testing results in tumor profiling grows louder, the need for rapid, reliable test methods becomes more pressing. Meanwhile, with new genetic biomarkers emerging at a rapid pace, “everything has tipped the balance toward comprehensive next-generation sequencing analysis,” said Maria E. Arcila, MD.
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Microscope to image—big lift but also a blueprint
April 2024—The Food and Drug Administration in February cleared Proscia’s Concentriq AP-Dx digital pathology software for the purpose of primary diagnosis.
Image Credits: [do_widget id=enhancedtextwidget-12].
Video Spotlight
-
Boost Your IHC Workflow and Increase Throughput of Cases
See the impact achieved in real-world customer settings with a holistic approach to tissue staining. Learn more. Read More »
CAP TODAY Recommends
-
Clinical Lab 2.0 honors laboratory team excellence
Clinical Lab 2.0, a Project Santa Fe Foundation initiative, released a proclamation during Medical Laboratory Professionals Week, April 14–20, to recognize and celebrate the roles of laboratory medicine and pathology in the field of medicine “as we transition from the business of volume to the business of value” in the delivery of integrated health care. Read the full proclamation here. Clinical Lab 2.0 was established to provide thought leadership and help develop the evidence base for the valuation of clinical laboratory services in the next era of global health care.
Read More »
CAP TODAY Webinars On-Demand
-
Liquid Biopsy and Concurrent Testing Strategies for Patients with Metastatic NSCLC
Webinar presenter Zin Htway, PhD, Supervisor and Operations Manager, Anatomic Pathology as HCA Los Robles Hospital and Medical Center, discusses the impact of liquid biopsy and concurrent biomarker testing for the appropriate care of patients with NSCLC. Read More » -
Combining Clinical Signs and Symptoms with Histopathology for Definitive Diagnosis of Idiopathic Multicentric Castleman Disease (iMCD)
Webinar presenter Jade Neff, MD, PhD, Assistant Professor of Pathology, Duke University Medical Center, discusses Definitive Diagnosis of Idiopathic Multicentric Castleman Disease (iMCD), including the pivotal role that pathologists play in diagnosing iMCD, an elusive and debilitating disease that poses unique diagnostic challenges.
Image Credits: [do_widget id=enhancedtextwidget-12].
REGISTER NOW
-
Register for our upcoming webinar
Genomic profile availability impact on NSCLC patient outcomes in real word study and daily practice
Read More »
Thursday, June 13, 2024, 1:00 PM–2:00 PM ET
Webinar presenters Melina Marmarelis, MD, MSCE, and Salvatore Fortunato Priore, MD, PhD, will discuss a real-world cohort study using electronic health records to assess the impact of the genomic profile availability to guide 1st line therapy on patient outcomes. They found that availability of molecular genotyping results before 1L therapy was associated with significantly better OS, and also, that concurrent tissue and plasma testing was associated with a higher odds of availability of results before 1L therapy. -
Register for our upcoming webinar
Virtual Roundtable: Optimizing Testing for the Diagnosis of Systemic Mastocytosis
June 25, 2024, 1:00 PM–2:00 PM ET
Webinar presenters Robyn Scherber, MD, MPH Hematologist UT Health SA, Medical Director Blueprint Medicines; Anton Rets, MD, PhD Associate Professor University of Utah, Medical Director Hematopathology and Immunohistochemistry; Nathan A. Boggs, MD, PhD Assistant Professor of Medicine, Uniformed Services University Allergy Division Director will discuss the barriers and possible solutions to screening for and diagnosing Systemic Mastocytosis (SM) and recommendations that will empower cross-functional laboratory stakeholders to implement changes that can help improve the diagnosis of SM.
Image Credits: [do_widget id=enhancedtextwidget-12].
AMP Case Reports
-
AMP case report: Use of molecular techniques to solve a challenging case of primary cutaneous marginal zone lymphoma
April 2024—Primary cutaneous marginal zone lymphoma (PCMZL) is a newly recognized, distinctive subtype of non-Hodgkin’s lymphoma. This low-grade lymphoma predominantly presents as papules or nodules within the skin of middle-aged adults. Formerly grouped under the extranodal marginal zone lymphoma (EMZL) category, the World Health Organization’s fifth edition classification of hematolymphoid tumors now recognizes PCMZL as a distinct entity.
Read More » -
AMP case report: Acute myeloid leukemia with hyperdiploidy
-
AMP case report: Potential von Hippel-Lindau syndrome in a patient with negative germline testing
-
AMP case report: Identification of multiple germline cancer predisposing gene variants in a single patient during tumor sequencing analysis
-
AMP case report: Lung micropapillary adenocarcinomas revisited
APRIL 2024
-
Confronting diagnostic gaps in fungal infection
April 2024—The rise in fungal infections in recent years troubles Sean Zhang, MD, PhD, for reasons near and far. It’s readily apparent in the patient populations at Johns Hopkins Hospital, where he is director of the mycology laboratory. Especially concerning is the increase in Candida auris following the height of the COVID-19 pandemic, both in terms of colonization and infection cases, says Dr. Zhang, who is also associate professor of pathology, Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine. “Since 2022, we suddenly saw an uptick in Candida auris cases across the Johns Hopkins Health System.” But the situation isn’t unique to Johns Hopkins. Pointing to CDC figures, he notes that the tide is rising more broadly as well. The agency reports that in 2020, there were 757 clinical cases and 1,310 screening cases of C. auris in the United States. In 2022, there were 2,377 clinical cases and 5,754 screening cases.
Read More » -
Hybrid practice model beckons as solution
April 2024—With the technology now available, could and should remote diagnostic pathology, or at least a hybrid model, become more the norm in the future? Timothy Craig Allen, MD, JD, and Casey P. Schukow, DO, of Corewell Health in Michigan, in an editorial published recently, say the time for one or the other or both has come.
-
Need for speed in solid tumor molecular testing
April 2024—As the call for fast turnaround of genetic testing results in tumor profiling grows louder, the need for rapid, reliable test methods becomes more pressing. Meanwhile, with new genetic biomarkers emerging at a rapid pace, “everything has tipped the balance toward comprehensive next-generation sequencing analysis,” said Maria E. Arcila, MD.
-
Microscope to image—big lift but also a blueprint
April 2024—The Food and Drug Administration in February cleared Proscia’s Concentriq AP-Dx digital pathology software for the purpose of primary diagnosis.
Image Credits: [do_widget id=enhancedtextwidget-12].
Video Spotlight
-
Boost Your IHC Workflow and Increase Throughput of Cases
See the impact achieved in real-world customer settings with a holistic approach to tissue staining. Learn more. Read More »
CAP TODAY Recommends
-
Clinical Lab 2.0 honors laboratory team excellence
Clinical Lab 2.0, a Project Santa Fe Foundation initiative, released a proclamation during Medical Laboratory Professionals Week, April 14–20, to recognize and celebrate the roles of laboratory medicine and pathology in the field of medicine “as we transition from the business of volume to the business of value” in the delivery of integrated health care. Read the full proclamation here. Clinical Lab 2.0 was established to provide thought leadership and help develop the evidence base for the valuation of clinical laboratory services in the next era of global health care.
Read More »
CAP TODAY Webinars On-Demand
-
Liquid Biopsy and Concurrent Testing Strategies for Patients with Metastatic NSCLC
Webinar presenter Zin Htway, PhD, Supervisor and Operations Manager, Anatomic Pathology as HCA Los Robles Hospital and Medical Center, discusses the impact of liquid biopsy and concurrent biomarker testing for the appropriate care of patients with NSCLC. Read More » -
Combining Clinical Signs and Symptoms with Histopathology for Definitive Diagnosis of Idiopathic Multicentric Castleman Disease (iMCD)
Webinar presenter Jade Neff, MD, PhD, Assistant Professor of Pathology, Duke University Medical Center, discusses Definitive Diagnosis of Idiopathic Multicentric Castleman Disease (iMCD), including the pivotal role that pathologists play in diagnosing iMCD, an elusive and debilitating disease that poses unique diagnostic challenges.
Image Credits: [do_widget id=enhancedtextwidget-12].
REGISTER NOW
-
Register for our upcoming webinar
Genomic profile availability impact on NSCLC patient outcomes in real word study and daily practice
Read More »
Thursday, June 13, 2024, 1:00 PM–2:00 PM ET
Webinar presenters Melina Marmarelis, MD, MSCE, and Salvatore Fortunato Priore, MD, PhD, will discuss a real-world cohort study using electronic health records to assess the impact of the genomic profile availability to guide 1st line therapy on patient outcomes. They found that availability of molecular genotyping results before 1L therapy was associated with significantly better OS, and also, that concurrent tissue and plasma testing was associated with a higher odds of availability of results before 1L therapy. -
Register for our upcoming webinar
Virtual Roundtable: Optimizing Testing for the Diagnosis of Systemic Mastocytosis
June 25, 2024, 1:00 PM–2:00 PM ET
Webinar presenters Robyn Scherber, MD, MPH Hematologist UT Health SA, Medical Director Blueprint Medicines; Anton Rets, MD, PhD Associate Professor University of Utah, Medical Director Hematopathology and Immunohistochemistry; Nathan A. Boggs, MD, PhD Assistant Professor of Medicine, Uniformed Services University Allergy Division Director will discuss the barriers and possible solutions to screening for and diagnosing Systemic Mastocytosis (SM) and recommendations that will empower cross-functional laboratory stakeholders to implement changes that can help improve the diagnosis of SM.
Image Credits: [do_widget id=enhancedtextwidget-12].
AMP Case Reports
-
AMP case report: Use of molecular techniques to solve a challenging case of primary cutaneous marginal zone lymphoma
April 2024—Primary cutaneous marginal zone lymphoma (PCMZL) is a newly recognized, distinctive subtype of non-Hodgkin’s lymphoma. This low-grade lymphoma predominantly presents as papules or nodules within the skin of middle-aged adults. Formerly grouped under the extranodal marginal zone lymphoma (EMZL) category, the World Health Organization’s fifth edition classification of hematolymphoid tumors now recognizes PCMZL as a distinct entity.
Read More » -
AMP case report: Acute myeloid leukemia with hyperdiploidy
-
AMP case report: Potential von Hippel-Lindau syndrome in a patient with negative germline testing
-
AMP case report: Identification of multiple germline cancer predisposing gene variants in a single patient during tumor sequencing analysis
-
AMP case report: Lung micropapillary adenocarcinomas revisited